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KMID : 1123920180320010035
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Korean Journal of Oriental Physiology and Pathology
2018 Volume.32 No. 1 p.35 ~ p.42
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Effects Study of Scutellariae Radix Extract on the Neuropathic Pain in Tibial and Common Peroneal Nerve Transected Rats
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Hwang Min-Seop
Kang Seok-Yong
Kang An-Na
Kim Su-Jin
Jung Hyo-Won
Park Yong-Ki
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Abstract
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TRPA1 and TRPV1 are members of the TRP superfamily of structurally related, nonselective cation channels. TRPA1 and TRPV1 are often co-expressed in sensory neurons and play an important role in mechanical hyperalgesia and allodynia during neuropathic pain. Scutellariae Radix was reported to possess anti-inflammation properties and similar patterns of therapeutic action against different diseases. also Baicalin(a known principal constituent of Scutellaria Radix) was shown to down-regulate the mRNA expression levels of TRPV1. In this study, we observed the effects of Scutellariae Radix extract(SRE) in neuropathic pain induced SD rats via modulation of TRPV1 and TRPA1. Oral administration of a Scutellaria Radix extract(in doses of 300mg/kg, SRE(300)) showed a meaningful increase in the withdrawal threshold of mechanical allodynia and showed a meaningful decrease in the expression of c-fos compared to the control group. SRE(100) and SRE(300) showed a meaningful decrease in the expression of TRPV1 level compared to the control group. These results suggest that Scutellariae Radix extract could decrease mechanical allodynia by down-regulate the TRPV1 on the model of neuropathic pain.
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KEYWORD
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Neuropathic pain, Scutellariae Radix, c-fos, TRPV1, TRPA1
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